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(inpatient) Treatment for Adolescents With Depression Study



In 1999, the National Institute of Mental Health funded the Treatment for Adolescents With Depression Study (TADS). This randomized, controlled trial demonstrated the effectiveness of Cognitive-Behavioural Therapy (CBT) in treating adolescent depression.


Research aim

The TADS manual was developed and evaluated for the outpatient setting yet many adolescents in Germany receive inpatient treatment for depression. The aim of the current study is to develop and test the feasibility of an adaptation of the TADS manual for the inpatient setting (i-TADS). The participants of the study are teenagers over 13 years, who are currently in inpatient treatment for depression in the Department of Child and Adolescent Psychiatry at the LMU Munich.

The manual treatment consist of 6 weekly sessions with the participant, 2 sessions with the participant and his/her parents and 2 sessions with the parents. In addition to the manual, the patient has an additional weekly session with a psychotherapist.

Before treatment a clinical diagnostic interview is conducted with the patient to assess eligibility for the study. The participant (and their caregiver) then completes measures of depression severity before, after and every week during the manual treatment phase. Where possible the diagnostic instrument is administered at the the end of treatment. This pre-post pilot study is designed to provide the foundations for a larger-scale randomised controlled trial (RCT) of the manual.